5cay: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor==

== Structural highlights ==

<table><tr><td colspan='2'>[[5cay]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CAY FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cay OCA], [http://pdbe.org/5cay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cay RCSB], [http://www.ebi.ac.uk/pdbsum/5cay PDBsum]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN]] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

== Publication Abstract from PubMed ==

HIV-2 is a non-pandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term non-progression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30-40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0 A structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence.

~~The entry 5cay is ON HOLD until Paper Publication~~

Structure of an HIV-2 gp120 in complex with CD4.,Davenport YW, West AP Jr, Bjorkman PJ J Virol. 2015 Nov 25. pii: JVI.02678-15. PMID:26608312<ref>PMID:26608312</ref>

~~Authors: Davenport~~, Y.W.~~, Bjorkman, P.J~~.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description~~: ~~Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor~~

[[Category: ~~Unreleased Structures~~]]

== References ==

[[Category: Davenport, Y.W]]

[[Category: ~~Bjorkman, P.J~~]]

__TOC__

</StructureSection>

[[Category: Bjorkman, P J]]

[[Category: Davenport, Y W]]

[[Category: Cd4]]

[[Category: Glycoprotein]]

[[Category: Gp120]]

[[Category: Hiv-2]]

[[Category: Viral protein-immune system complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor==
+<StructureSection load='5cay' size='340' side='right' caption='[[5cay]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5cay]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CAY FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cay FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cay OCA], [http://pdbe.org/5cay PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cay RCSB], [http://www.ebi.ac.uk/pdbsum/5cay PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN]] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+HIV-2 is a non-pandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term non-progression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30-40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0 A structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence.
-The entry 5cay is ON HOLD  until Paper Publication
+Structure of an HIV-2 gp120 in complex with CD4.,Davenport YW, West AP Jr, Bjorkman PJ J Virol. 2015 Nov 25. pii: JVI.02678-15. PMID:26608312<ref>PMID:26608312</ref>
-Authors: Davenport, Y.W., Bjorkman, P.J.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor
+<div class="pdbe-citations 5cay" style="background-color:#fffaf0;"></div>
-[[Category: Unreleased Structures]]
+== References ==
-[[Category: Davenport, Y.W]]
+<references/>
-[[Category: Bjorkman, P.J]]
+__TOC__
+</StructureSection>
+[[Category: Bjorkman, P J]]
+[[Category: Davenport, Y W]]
+[[Category: Cd4]]
+[[Category: Glycoprotein]]
+[[Category: Gp120]]
+[[Category: Hiv-2]]
+[[Category: Viral protein-immune system complex]]