TNF receptor-associated factor: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1d01' size='340' side='right' caption='Human TRAF2 TRAF domain complex with CD30 peptide (PDB code 1d01)' scene=''> '''TNF receptor-associated factor''' (TRAF)... |
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<StructureSection load='1f3v' size='340' side='right' caption='Human TRAF2 TRAF domain complex with CD30 peptide (PDB code [[1d01]])' scene=''> | |||
<StructureSection load=' | |||
'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins. TRAF2-6 have N-terminal RING and zinc finger motifs. TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK. | '''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins. TRAF2-6 have N-terminal RING and zinc finger motifs. TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK. | ||
