TNF receptor-associated factor

spinqualitylabelsall models Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein (grey) (PDB code 1d01) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D TNF receptor-associated factor (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins. TRAF2-6 have N-terminal RING and zinc finger motifs. TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK.

3D Structures of TNF receptor-associated factor

Updated on 23-July-2015

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• TRAF1
  • 3m0d – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 - human
    
• TRAF2
  • 1ca4 – hTRAF2 TRAF domain
    
  • 3knv – hTRAF2 RING+zinc finger 1 domains
    
  • 3m06 – hTRAF2 residues 266-329
    
• TRAF2 complex with peptide
  • 1ca9 – hTRAF2 TRAF domain + TNF-R2 peptide
    
  • 1qsc, 1d00, 1czz – hTRAF2 TRAF domain + CD40 receptor peptide
    
  • 1d01 – hTRAF2 TRAF domain + CD30 peptide
    
  • 1czy – hTRAF2 TRAF domain + latent membrane protein peptide
    
  • 1d0a – hTRAF2 TRAF domain + OX40L receptor peptide
    
  • 1d0j – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide
    
  • 1f3v – hTRAF2 TRAF domain + TRADD N terminal
    
  • 3m0a – hTRAF2 residues 266-329 + cIAP2
    
• TRAF6
  • 1lb4 – hTRAF6 TRAF domain
    
  • 2jmd, 2eci – hTRAF6 RING domain - NMR
    
  • 3hcs – hTRAF6 RING+zinc finger 1-3 domains
    
• TRAF6 complex with peptide
  • 1lb5 – hTRAF6 TRAF domain + RANK peptide
    
  • 1lb6 – hTRAF6 TRAF domain + CD40 antigen peptide
    
  • 3hct, 3hcu – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2
    

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