5ccj: Difference between revisions
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''' | ==Crystal structure of the quintuple mutant of the synaptotagmin-1 C2B domain== | ||
<StructureSection load='5ccj' size='340' side='right' caption='[[5ccj]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ccj]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CCJ FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ccj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ccj RCSB], [http://www.ebi.ac.uk/pdbsum/5ccj PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Brunger, A T]] | |||
[[Category: Zhao, M]] | |||
[[Category: Zhou, Q]] | [[Category: Zhou, Q]] | ||
[[Category: | [[Category: C2b domain]] | ||
[[Category: | [[Category: Signaling protein]] | ||
[[Category: Synaptotagmin1]] | |||
Revision as of 14:54, 12 August 2015
Crystal structure of the quintuple mutant of the synaptotagmin-1 C2B domain
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