2ms8: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Solution NMR structure of MAVS CARD==

~~The entry~~ 2ms8 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[2ms8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MS8 FirstGlance]. <br>

~~Authors~~: ~~Spehr, J~~.~~, He, L~~.~~, Luehrs, T~~.~~, Ritter, C~~.

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ms7|2ms7]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ms8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ms8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms8 PDBsum]</span></td></tr>

~~Description~~: ~~Solution NMR structure of MAVS CARD~~

</table>

[[~~Category~~: ~~Unreleased Structures~~]]

== Function ==

[[~~Category~~: ~~Spehr~~, J]]

[[http://www.uniprot.org/uniprot/MAVS_HUMAN MAVS_HUMAN]] Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.<ref>PMID:16125763</ref> <ref>PMID:16153868</ref> <ref>PMID:16177806</ref> <ref>PMID:16127453</ref> <ref>PMID:19631370</ref> <ref>PMID:20451243</ref>

[[~~Category~~: ~~Ritter, C~~]]

== References ==

__TOC__

</StructureSection>

[[Category: He, L]]

[[Category: Luehrs, T]]

[[Category: Ritter, C]]

[[Category: Spehr, J]]

[[Category: Mavs card]]

[[Category: Protein binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Solution NMR structure of MAVS CARD==
+<StructureSection load='2ms8' size='340' side='right' caption='[[2ms8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-The entry 2ms8 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ms8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MS8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MS8 FirstGlance]. <br>
-Authors: Spehr, J., He, L., Luehrs, T., Ritter, C.
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ms7|2ms7]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ms8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ms8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ms8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ms8 PDBsum]</span></td></tr>
-Description: Solution NMR structure of MAVS CARD
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Spehr, J]]
+[[http://www.uniprot.org/uniprot/MAVS_HUMAN MAVS_HUMAN]] Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.<ref>PMID:16125763</ref> <ref>PMID:16153868</ref> <ref>PMID:16177806</ref> <ref>PMID:16127453</ref> <ref>PMID:19631370</ref> <ref>PMID:20451243</ref>
-[[Category: Ritter, C]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: He, L]]
 [[Category: Luehrs, T]]
+[[Category: Ritter, C]]
+[[Category: Spehr, J]]
+[[Category: Mavs card]]
+[[Category: Protein binding]]