5cui: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5cui is ~~ON HOLD until Paper Publication~~

==Crystal structure of Human Defensin-5 R28A mutant.==

~~Authors~~: ~~Tolbert~~, W.D., ~~Gohain~~, N., ~~Pazgier~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[5cui]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUI OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CUI FirstGlance].

~~Description~~: ~~Crystal structure of Human Defensin~~-~~5 R28A mutant~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[1zmp|1zmp]], [[5cuj|5cuj]], [[5cum|5cum]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cui OCA], [http://pdbe.org/5cui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cui RCSB], [http://www.ebi.ac.uk/pdbsum/5cui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cui ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Gohain, N]]

[[Category: Pazgier, M]]

[[Category: Tolbert, W.D]]

[[Category: Tolbert, W D]]

[[Category: ~~Gohain, N~~]]

[[Category: Antimicrobial protein]]

[[Category: Human alpha-defensin]]

[[Category: Intestinal defensin]]

[[Category: Paneth cells defensin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5cui is ON HOLD  until Paper Publication
+==Crystal structure of Human Defensin-5 R28A mutant.==
+<StructureSection load='5cui' size='340' side='right' caption='[[5cui]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Tolbert, W.D., Gohain, N., Pazgier, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5cui]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CUI FirstGlance]. <br>
-Description: Crystal structure of Human Defensin-5 R28A mutant.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zmp|1zmp]], [[5cuj|5cuj]], [[5cum|5cum]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cui OCA], [http://pdbe.org/5cui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cui RCSB], [http://www.ebi.ac.uk/pdbsum/5cui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cui ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gohain, N]]
 [[Category: Pazgier, M]]
-[[Category: Tolbert, W.D]]
+[[Category: Tolbert, W D]]
-[[Category: Gohain, N]]
+[[Category: Antimicrobial protein]]
+[[Category: Human alpha-defensin]]
+[[Category: Intestinal defensin]]
+[[Category: Paneth cells defensin]]