WD repeat-containing protein: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 complex with histone H3 peptide (PDB code 2h9m)''> '''WD-repeat protein 5''' (WDR5) contains 7... |
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<StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 (grey and pink) complex with histone H3 peptide (green and yellow) (PDB code [[2h9m]])'> | |||
<StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 complex with histone H3 peptide (PDB code [[2h9m]]) | |||
'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL). WDR5 forms a beta propeller structure. | '''WD-repeat protein 5''' (WDR5) contains 7 WD repeats. WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD). WDR5 contributes to histone modification. It may position the N-terminal of histone H3 for efficient methylation at Lys4. This methylation is implicated in the control of activation of cell lineage genes during embryogenesis. WDR5 interacts with histone-lysine N-methyltransferase (MLL). WDR5 forms a beta propeller structure. | ||
