WD repeat-containing protein: Difference between revisions

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<StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 (grey and pink) complex with histone H3 peptide (green and yellow) (PDB code [[2h9m]])'>
<StructureSection load='2h9m' size='340' side='right' caption='Human WD-repeat protein 5 (grey) complex with histone H3 peptide (green) (PDB code [[2h9m]])'>
'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats.  WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD).  WDR5 contributes to histone modification.  It may position the N-terminal of histone H3 for efficient methylation at Lys4.  This methylation is implicated in the control of activation of cell lineage genes during embryogenesis.  WDR5 interacts with histone-lysine N-methyltransferase (MLL).  WDR5 forms a beta propeller structure.
 
== Function ==
== Function ==
'''WD-repeat protein 5''' (WDR5) contains 7 WD repeats.  WD repeats are ca. 40 amino acid long usually bordered by Gly-His and Trp-Asp (WD).  WDR5 contributes to histone modification.  It may position the N-terminal of histone H3 for efficient methylation at Lys4.  This methylation is implicated in the control of activation of cell lineage genes during embryogenesis.  WDR5 interacts with histone-lysine N-methyltransferase (MLL)<ref>PMID:21531708</ref>.  WDR5 forms a beta propeller structure.


== Disease ==
== Disease ==
Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.


== Relevance ==
== Relevance ==
Retrieved from "https://proteopedia.org/WD_repeat-containing_protein"