3jav: Difference between revisions
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''' | ==Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM== | ||
<StructureSection load='3jav' size='340' side='right' caption='[[3jav]], [[Resolution|resolution]] 4.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3jav]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JAV FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jav OCA], [http://pdbe.org/3jav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jav RCSB], [http://www.ebi.ac.uk/pdbsum/3jav PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[Category: | [[http://www.uniprot.org/uniprot/ITPR1_RAT ITPR1_RAT]] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). | ||
[[Category: Baker, M | __TOC__ | ||
[[Category: Baker, M | </StructureSection> | ||
[[Category: Rattus norvegicus]] | |||
[[Category: Baker, M L]] | |||
[[Category: Baker, M R]] | |||
[[Category: Chiu, W]] | |||
[[Category: Fan, G]] | [[Category: Fan, G]] | ||
[[Category: | [[Category: Ludtke, S J]] | ||
[[Category: Serysheva, I I]] | |||
[[Category: Serysheva, I | [[Category: Sinyagovskiy, P A]] | ||
[[Category: | |||
[[Category: Wang, Z]] | [[Category: Wang, Z]] | ||
[[Category: 5-trisphosphate receptor]] | |||
[[Category: Calcium release channel]] | |||
[[Category: Calcium signaling]] | |||
[[Category: Inositol 1]] | |||
[[Category: Transport protein]] | |||
Revision as of 13:47, 7 October 2015
Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM
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