1atn: Difference between revisions

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|PDB= 1atn |SIZE=350|CAPTION= <scene name='initialview01'>1atn</scene>, resolution 2.8&Aring;
|PDB= 1atn |SIZE=350|CAPTION= <scene name='initialview01'>1atn</scene>, resolution 2.8&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CH3:METHYL+GROUP'>CH3</scene> and <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CH3:METHYL+GROUP'>CH3</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
|ACTIVITY=  
|ACTIVITY=  
|GENE=  
|GENE=  
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1atn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1atn OCA], [http://www.ebi.ac.uk/pdbsum/1atn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1atn RCSB]</span>
}}
}}


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==Overview==
==Overview==
The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined by X-ray analysis at an effective resolution of 2.8 A and 3A, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta meander and a right handed beta alpha beta unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase.
The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined by X-ray analysis at an effective resolution of 2.8 A and 3A, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta meander and a right handed beta alpha beta unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase.
==Disease==
Known diseases associated with this structure: Myopathy, actin, congenital, with cores OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102610 102610]], Myopathy, actin, congenital, with excess of thin myofilaments OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102610 102610]], Myopathy, congenital, with fiber-type disporportion 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102610 102610]], Myopathy, nemaline, 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102610 102610]]


==About this Structure==
==About this Structure==
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[[Category: Pai, E.]]
[[Category: Pai, E.]]
[[Category: Suck, D.]]
[[Category: Suck, D.]]
[[Category: ACE]]
[[Category: ATP]]
[[Category: CA]]
[[Category: CH3]]
[[Category: endodeoxyribonuclease]]
[[Category: endodeoxyribonuclease]]


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