SCF-KIT: Difference between revisions
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SCF-KIT interface can be divided to three: SiteI, Site II and Site III. | SCF-KIT interface can be divided to three: SiteI, Site II and Site III. | ||
The dimerization of KIT is made possible by <scene name='70/702908/Scf_bound_to_kit/1'>bivalent SCF binding,</scene> whose sole function is to bind SCF and to bring together two KIT molecules. This dimerization is followed by a large change in D4 and D5 orientations. It was proposed that the flexible joints at the D3-D4 and D4-D5 interfaces enable lateral interactions that result in a large conformational change upon receptor dimerization. In the process of dimerization, there is a selection between particular conformations in a transition from a flexibly jointed monomer to a rigid dimer. | The dimerization of KIT is made possible by <scene name='70/702908/Scf_bound_to_kit/1'>bivalent SCF binding,</scene> whose sole function is to bind SCF and to bring together two KIT molecules. This dimerization is followed by a large change in D4 and D5 orientations. It was proposed that the flexible joints at the D3-D4 and D4-D5 interfaces enable lateral interactions that result in a large conformational change upon receptor dimerization. In the process of dimerization, there is a selection between particular conformations in a transition from a flexibly jointed monomer to a rigid dimer. | ||
A similar mechanism was found in [https://en.wikipedia.org/wiki/VEGF_receptors VEGFR] | A similar mechanism was found in [https://en.wikipedia.org/wiki/VEGF_receptors VEGFR] (vascular endothelial growth factor receptor). | ||
VEGFR takes part in regulation of blood and lymphatic vessel development and homeostasis. | VEGFR takes part in regulation of blood and lymphatic vessel development and homeostasis. | ||
