5ac2: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==human aldehyde dehydrogenase 1A1 with duocarmycin analog==

~~The entry~~ 5ac2 is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5ac2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AC2 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AC2 FirstGlance].

~~Authors~~: ~~Koch~~, ~~M.F.~~, ~~Harteis~~, S., ~~Blank~~, ~~I.D.~~, ~~Pestel~~, G., ~~Tietze~~, L.F., ~~Ochsenfeld~~, C., ~~Schneider~~, S.~~, Sieber, S~~.A.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=K9P:1-[(1S)-1-METHYL-5-OXIDANYL-1,2-DIHYDROBENZO[E]INDOL-3-YL]HEXAN-1-ONE'>K9P</scene>, <scene name='pdbligand=TXE:[[(2R,3S,4R,5R)-5-[(3R)-3-AMINOCARBONYL-3,4-DIHYDRO-2H-PYRIDIN-1-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANIDYL-PHOSPHORYL]+[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+PHOSPHATE'>TXE</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5abm|5abm]], [[5ac0|5ac0]], [[5ac1|5ac1]]</td></tr>

~~Description~~: ~~human aldehyde~~ dehydrogenase ~~1A1 with duocarmycin analog~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Retinal_dehydrogenase Retinal dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.36 1.2.1.36] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ac2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ac2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ac2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ac2 PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/AL1A1_HUMAN AL1A1_HUMAN]] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).

__TOC__

</StructureSection>

[[Category: Retinal dehydrogenase]]

[[Category: Blank, I D]]

[[Category: Harteis, S]]

[[Category: Koch, M F]]

[[Category: Ochsenfeld, C]]

[[Category: Pestel, G]]

~~[[Category: Sieber, S.A]]~~

~~[[Category: Tietze, L.F]]~~

[[Category: Schneider, S]]

[[Category: ~~Harteis~~, S]]

[[Category: Sieber, S A]]

[[Category: ~~Blank~~, ~~I.D~~]]

[[Category: Tietze, L F]]

[[Category: ~~Koch, M.F~~]]

[[Category: Aldehyde dehydrogenase activity]]

[[Category: ~~Ochsenfeld, C~~]]

[[Category: Oxidation-reduction process]]

[[Category: Oxidoreductase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==human aldehyde dehydrogenase 1A1 with duocarmycin analog==
+<StructureSection load='5ac2' size='340' side='right' caption='[[5ac2]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-The entry 5ac2 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ac2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AC2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AC2 FirstGlance]. <br>
-Authors: Koch, M.F., Harteis, S., Blank, I.D., Pestel, G., Tietze, L.F., Ochsenfeld, C., Schneider, S., Sieber, S.A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K9P:1-[(1S)-1-METHYL-5-OXIDANYL-1,2-DIHYDROBENZO[E]INDOL-3-YL]HEXAN-1-ONE'>K9P</scene>, <scene name='pdbligand=TXE:[[(2R,3S,4R,5R)-5-[(3R)-3-AMINOCARBONYL-3,4-DIHYDRO-2H-PYRIDIN-1-YL]-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANIDYL-PHOSPHORYL]+[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHYL+PHOSPHATE'>TXE</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5abm|5abm]], [[5ac0|5ac0]], [[5ac1|5ac1]]</td></tr>
-Description: human aldehyde dehydrogenase 1A1 with duocarmycin analog
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Retinal_dehydrogenase Retinal dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.36 1.2.1.36] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ac2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ac2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ac2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ac2 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/AL1A1_HUMAN AL1A1_HUMAN]] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Retinal dehydrogenase]]
+[[Category: Blank, I D]]
+[[Category: Harteis, S]]
+[[Category: Koch, M F]]
+[[Category: Ochsenfeld, C]]
 [[Category: Pestel, G]]
-[[Category: Sieber, S.A]]
-[[Category: Tietze, L.F]]
 [[Category: Schneider, S]]
-[[Category: Harteis, S]]
+[[Category: Sieber, S A]]
-[[Category: Blank, I.D]]
+[[Category: Tietze, L F]]
-[[Category: Koch, M.F]]
+[[Category: Aldehyde dehydrogenase activity]]
-[[Category: Ochsenfeld, C]]
+[[Category: Oxidation-reduction process]]
+[[Category: Oxidoreductase]]