1fml: Difference between revisions
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|PDB= 1fml |SIZE=350|CAPTION= <scene name='initialview01'>1fml</scene>, resolution 2.75Å | |PDB= 1fml |SIZE=350|CAPTION= <scene name='initialview01'>1fml</scene>, resolution 2.75Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3'-5'-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1fmj|1FMJ]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fml OCA], [http://www.ebi.ac.uk/pdbsum/1fml PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fml RCSB]</span> | |||
}} | }} | ||
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[[Category: Newcomer, M E.]] | [[Category: Newcomer, M E.]] | ||
[[Category: Pakhomova, S.]] | [[Category: Pakhomova, S.]] | ||
[[Category: | [[Category: adenosine 3',5'-diphosphate]] | ||
[[Category: dehydratase]] | [[Category: dehydratase]] | ||
[[Category: retinol]] | [[Category: retinol]] | ||
[[Category: sulfotransferase]] | [[Category: sulfotransferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:25:56 2008'' | ||
Revision as of 17:26, 30 March 2008
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| 1fml, resolution 2.75Å | |||||||||||||
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| Ligands: | A3P, CA, RTL | ||||||||||||
| Related: | 1FMJ
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF RETINOL DEHYDRATASE IN A COMPLEX WITH RETINOL AND PAP
Overview
We report here the crystal structure of retinol dehydratase, an enzyme that catalyzes the synthesis of anhydroretinol. The enzyme is a member of the sulfotransferase superfamily and its crystal structure reveals the insertion of a helical lid into a canonical sulfotransferase fold. Site-directed mutations demonstrate that this inserted lid is necessary for anhydroretinol production but not for sulfonation; thus, insertion of a helical lid can convert a sulfotransferase into a dehydratase.
About this Structure
1FML is a Single protein structure of sequence from Spodoptera frugiperda. Full crystallographic information is available from OCA.
Reference
A helical lid converts a sulfotransferase to a dehydratase., Pakhomova S, Kobayashi M, Buck J, Newcomer ME, Nat Struct Biol. 2001 May;8(5):447-51. PMID:11323722
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