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'''Unreleased structure'''
==Iridoid synthase from Catharanthus roseus - ternary complex with NADP+ and geranic acid==
<StructureSection load='5df1' size='340' side='right' caption='[[5df1]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5df1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DF1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=58X:(2E)-3,7-DIMETHYLOCTA-2,6-DIENOIC+ACID'>58X</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iridoid_synthase Iridoid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.99 1.3.1.99] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5df1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5df1 OCA], [http://pdbe.org/5df1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5df1 RCSB], [http://www.ebi.ac.uk/pdbsum/5df1 PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (from Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homolog progesterone 5beta-reductase are highlighted.


The entry 5df1 is ON HOLD  until Paper Publication
Structural determinants of reductive terpene cyclization in iridoid biosynthesis.,Kries H, Caputi L, Stevenson CE, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE Nat Chem Biol. 2015 Nov 9. doi: 10.1038/nchembio.1955. PMID:26551396<ref>PMID:26551396</ref>


Authors: Caputi, L., Kries, H., Stevenson, C.E.M., Kamileen, M.O., Sherden, N.H., Geu-Flores, F., Lawson, D.M., O'Connor, S.E.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description:
<div class="pdbe-citations 5df1" style="background-color:#fffaf0;"></div>
[[Category: Unreleased Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Iridoid synthase]]
[[Category: Caputi, L]]
[[Category: Connor, S E.O]]
[[Category: Geu-Flores, F]]
[[Category: Kamileen, M O]]
[[Category: Kries, H]]
[[Category: Kries, H]]
[[Category: Geu-Flores, F]]
[[Category: Lawson, D M]]
[[Category: Sherden, N.H]]
[[Category: Sherden, N H]]
[[Category: Kamileen, M.O]]
[[Category: Stevenson, C E.M]]
[[Category: Stevenson, C.E.M]]
[[Category: Catharanthus roseus]]
[[Category: O'Connor, S.E]]
[[Category: Nadph-dependent]]
[[Category: Caputi, L]]
[[Category: Oxidoreductase]]
[[Category: Lawson, D.M]]
[[Category: Short chain dehydrogenase]]
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