4x3o: Difference between revisions
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''' | ==Sirt2 in complex with a myristoyl peptide== | ||
<StructureSection load='4x3o' size='340' side='right' caption='[[4x3o]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4x3o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X3O FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3Y0:[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]+[(2R,3R,4R,5R)-3-OXIDANYL-5-SULFANYL-4-TRIDECOXY-OXOLAN-2-YL]METHYL+HYDROGEN+PHOSPHATE'>3Y0</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x3p|4x3p]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3o OCA], [http://pdbe.org/4x3o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x3o RCSB], [http://www.ebi.ac.uk/pdbsum/4x3o PDBsum]</span></td></tr> | |||
[[ | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN]] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Hao, Q]] | [[Category: Hao, Q]] | ||
[[Category: Wang, Y]] | [[Category: Wang, Y]] | ||
[[Category: Zhang, W Z]] | |||
[[Category: Complex]] | |||
[[Category: Hydrolase-peptide complex]] | |||
[[Category: Myristoyl peptide]] | |||
[[Category: Sirt2]] | |||
Revision as of 20:21, 13 January 2016
Sirt2 in complex with a myristoyl peptide
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