5bve: Difference between revisions
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==Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase== | ==Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase== | ||
<StructureSection load='5bve' size='340' side='right' caption='[[5bve]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='5bve' size='340' side='right'caption='[[5bve]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5bve]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVE FirstGlance]. <br> | <table><tr><td colspan='2'>[[5bve]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BVE FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4VG:2-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-8-[2-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PYRIMIDIN-4-YL]-2,3,4,5-TETRAHYDRO-1H-PYRROLO[1,2-A][1,4]DIAZEPIN-1-ONE'>4VG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4VG:2-[(1S)-1-(3-CHLOROPHENYL)-2-HYDROXYETHYL]-8-[2-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PYRIMIDIN-4-YL]-2,3,4,5-TETRAHYDRO-1H-PYRROLO[1,2-A][1,4]DIAZEPIN-1-ONE'>4VG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bvd|5bvd]], [[5bvf|5bvf]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bvd|5bvd]], [[5bvf|5bvf]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAPK1, ERK2, PRKM1, PRKM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bve OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bve RCSB], [http://www.ebi.ac.uk/pdbsum/5bve PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bve OCA], [http://pdbe.org/5bve PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bve RCSB], [http://www.ebi.ac.uk/pdbsum/5bve PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bve ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 5bve" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Mitogen-activated protein kinase 3D structures|Mitogen-activated protein kinase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Mitogen-activated protein kinase]] | [[Category: Mitogen-activated protein kinase]] | ||
[[Category: Ma, X]] | [[Category: Ma, X]] | ||
