1mky: Difference between revisions
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|PDB= 1mky |SIZE=350|CAPTION= <scene name='initialview01'>1mky</scene>, resolution 1.90Å | |PDB= 1mky |SIZE=350|CAPTION= <scene name='initialview01'>1mky</scene>, resolution 1.90Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mky OCA], [http://www.ebi.ac.uk/pdbsum/1mky PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mky RCSB]</span> | |||
}} | }} | ||
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[[Category: Robinson, V L.]] | [[Category: Robinson, V L.]] | ||
[[Category: Stock, A M.]] | [[Category: Stock, A M.]] | ||
[[Category: der]] | [[Category: der]] | ||
[[Category: enga]] | [[Category: enga]] | ||
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[[Category: tandem g-domain]] | [[Category: tandem g-domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:17:33 2008'' | ||
Revision as of 19:17, 30 March 2008
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| 1mky, resolution 1.90Å | |||||||||||||
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| Ligands: | GDP, MSE, PO4 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Structural Analysis of the Domain Interactions in Der, a Switch Protein Containing Two GTPase Domains
Overview
The EngA subfamily of essential bacterial GTPases has a unique domain structure consisting of two adjacent GTPase domains (GD1 and GD2) and a C-terminal domain. The structure of Thermotoga maritima Der bound to GDP determined at 1.9 A resolution reveals a novel domain arrangement in which the GTPase domains pack at either side of the C-terminal domain. Unexpectedly, the C-terminal domain resembles a KH domain, missing the distinctive RNA recognition elements. Conserved motifs of the nucleotide binding site of GD1 are integral parts of the GD1-KH domain interface, suggesting the interactions between these two domains are directly influenced by the GTP/GDP cycling of the protein. In contrast, the GD2-KH domain interface is distal to the GDP binding site of GD2.
About this Structure
1MKY is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
Domain arrangement of Der, a switch protein containing two GTPase domains., Robinson VL, Hwang J, Fox E, Inouye M, Stock AM, Structure. 2002 Dec;10(12):1649-58. PMID:12467572
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