1tvk: Difference between revisions
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|PDB= 1tvk |SIZE=350|CAPTION= <scene name='initialview01'>1tvk</scene>, resolution 2.89Å | |PDB= 1tvk |SIZE=350|CAPTION= <scene name='initialview01'>1tvk</scene>, resolution 2.89Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP | |LIGAND= <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1jff|1JFF]], [[1tub|1TUB]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tvk OCA], [http://www.ebi.ac.uk/pdbsum/1tvk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tvk RCSB]</span> | |||
}} | }} | ||
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[[Category: Nettles, J H.]] | [[Category: Nettles, J H.]] | ||
[[Category: Snyder, J P.]] | [[Category: Snyder, J P.]] | ||
[[Category: | [[Category: epothilone]] | ||
[[Category: | [[Category: ligand interaction]] | ||
[[Category: | [[Category: taxol]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:40 2008'' | ||
Revision as of 21:01, 30 March 2008
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| 1tvk, resolution 2.89Å | |||||||||||||
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| Ligands: | EP, GDP, GTP | ||||||||||||
| Related: | 1JFF, 1TUB
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
The binding mode of epothilone A on a,b-tubulin by electron crystallography
Overview
The structure of epothilone A, bound to alpha,beta-tubulin in zinc-stabilized sheets, was determined by a combination of electron crystallography at 2.89 angstrom resolution and nuclear magnetic resonance-based conformational analysis. The complex explains both the broad-based epothilone structure-activity relationship and the known mutational resistance profile. Comparison with Taxol shows that the longstanding expectation of a common pharmacophore is not met, because each ligand exploits the tubulin-binding pocket in a unique and independent manner.
About this Structure
1TVK is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.
Reference
The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography., Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH, Science. 2004 Aug 6;305(5685):866-9. PMID:15297674
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