2oxw: Difference between revisions

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|PDB= 2oxw |SIZE=350|CAPTION= <scene name='initialview01'>2oxw</scene>, resolution 1.15&Aring;
|PDB= 2oxw |SIZE=350|CAPTION= <scene name='initialview01'>2oxw</scene>, resolution 1.15&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span>
|GENE= MMP12, HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= MMP12, HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|DOMAIN=
|RELATEDENTRY=[[2oxu|2OXU]], [[1y93|1Y93]], [[1rmz|1RMZ]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oxw OCA], [http://www.ebi.ac.uk/pdbsum/2oxw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oxw RCSB]</span>
}}
}}


'''Human MMP-12 complexed with the peptide IAG'''
'''Human MMP-12 complexed with the peptide IAG'''


==Disease==
Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Cardiomyopathy, familial hypertrophic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Muscular dystrophy, limb-girdle, type 2J OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Myopathy, proximal, with early respiratory muscle involvement OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]], Tibial muscular dystrophy, tardive OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=188840 188840]]


==About this Structure==
==About this Structure==
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[[Category: Maletta, M.]]
[[Category: Maletta, M.]]
[[Category: Yeo, K J.]]
[[Category: Yeo, K J.]]
[[Category: CA]]
[[Category: ZN]]
[[Category: matrix metalloproteinase]]
[[Category: matrix metalloproteinase]]
[[Category: mmp-12]]
[[Category: mmp-12]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:35:41 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:24:54 2008''

Revision as of 01:24, 31 March 2008

File:2oxw.jpg


Drag the structure with the mouse to rotate
2oxw, resolution 1.15Å
Ligands: CA, ZN
Gene: MMP12, HME (Homo sapiens)
Activity: Macrophage elastase, with EC number 3.4.24.65
Related: 2OXU, 1Y93, 1RMZ


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Human MMP-12 complexed with the peptide IAG


About this Structure

2OXW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Snapshots of the reaction mechanism of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ, Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:17096442

Page seeded by OCA on Mon Mar 31 04:24:54 2008

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