2hwb: Difference between revisions

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==A ~~COMPARISON OF THE ANTI~~-~~RHINOVIRAL DRUG BINDING POCKET IN HRV14 AND HRV1A~~==

==A comparison of the anti-rhinoviral drug binding pocket in hrv14 and hrv1a==

== Structural highlights ==

<table><tr><td colspan='2'>[[2hwb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrv-14 Hrv-14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HWB FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W91:5-(3-(2,6-DICHLORO-4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)PROPYL)-3-METHYL+ISOXAZOLE'>W91</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hwb OCA], [http://pdbe.org/2hwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hwb RCSB], [http://www.ebi.ac.uk/pdbsum/2hwb PDBsum]</span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hwb OCA], [http://pdbe.org/2hwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hwb RCSB], [http://www.ebi.ac.uk/pdbsum/2hwb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hwb ProSAT]</span></td></tr>

</table>

== Function ==

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Line 13:

Check<jmol>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/2hwb_consurf.spt"</scriptWhenChecked>

<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/2hwb_consurf.spt"</scriptWhenChecked>

<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>

<text>to colour the structure by Evolutionary Conservation</text>

</jmolCheckbox>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hwb ConSurf].

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@@ Line 1: / Line 1: @@
-==A COMPARISON OF THE ANTI-RHINOVIRAL DRUG BINDING POCKET IN HRV14 AND HRV1A==
+==A comparison of the anti-rhinoviral drug binding pocket in hrv14 and hrv1a==
 <StructureSection load='2hwb' size='340' side='right' caption='[[2hwb]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2hwb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hrv-14 Hrv-14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HWB FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W91:5-(3-(2,6-DICHLORO-4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)PROPYL)-3-METHYL+ISOXAZOLE'>W91</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hwb OCA], [http://pdbe.org/2hwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hwb RCSB], [http://www.ebi.ac.uk/pdbsum/2hwb PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hwb OCA], [http://pdbe.org/2hwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hwb RCSB], [http://www.ebi.ac.uk/pdbsum/2hwb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hwb ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 13: @@
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/2hwb_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hw/2hwb_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hwb ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">