2n7t: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==NMR structure of Peptide PG-992 in DPC micelles==

== Structural highlights ==

<table><tr><td colspan='2'>[[2n7t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7T FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7t OCA], [http://pdbe.org/2n7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7t RCSB], [http://www.ebi.ac.uk/pdbsum/2n7t PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated patho-physiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective lig-ands. Here, we report the design, synthesis, biological activity, conformational analysis and docking with receptors of two potent and selective agonists at the human MC3 receptor.

~~The entry 2n7t is ON HOLD~~

Discovery of Novel Potent and Selective Agonists at the Melanocortin3 Receptor.,Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P J Med Chem. 2015 Nov 24. PMID:26599352<ref>PMID:26599352</ref>

~~Authors: Carotenuto~~, A.~~, Merlino, F~~.~~, Chai, M~~., Brancaccio, D~~., Yousif, A., Novellino, E., Hruby, V., Grieco, P.~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description: NMR structure of Peptide PG-992 in DPC micelles~~

[[Category: ~~Unreleased Structures~~]]

== References ==

[[Category: ~~Novellino~~, E]]

__TOC__

</StructureSection>

[[Category: Brancaccio, D]]

[[Category: Carotenuto, A]]

[[Category: Chai, M]]

[[Category: Grieco, P]]

~~[[Category: Brancaccio, D]]~~

[[Category: Hruby, V]]

[[Category: Merlino, F]]

[[Category: Novellino, E]]

[[Category: Yousif, A]]

[[Category: ~~Carotenuto, A]]~~

[[Category: De novo protein]]

~~[[Category: Merlino, F]]~~

~~[[Category: Chai, M~~]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==NMR structure of Peptide PG-992 in DPC micelles==
+<StructureSection load='2n7t' size='340' side='right' caption='[[2n7t]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2n7t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N7T FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n7t OCA], [http://pdbe.org/2n7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n7t RCSB], [http://www.ebi.ac.uk/pdbsum/2n7t PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated patho-physiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective lig-ands. Here, we report the design, synthesis, biological activity, conformational analysis and docking with receptors of two potent and selective agonists at the human MC3 receptor.
-The entry 2n7t is ON HOLD
+Discovery of Novel Potent and Selective Agonists at the Melanocortin3 Receptor.,Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P J Med Chem. 2015 Nov 24. PMID:26599352<ref>PMID:26599352</ref>
-Authors: Carotenuto, A., Merlino, F., Chai, M., Brancaccio, D., Yousif, A., Novellino, E., Hruby, V., Grieco, P.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: NMR structure of Peptide PG-992 in DPC micelles
+<div class="pdbe-citations 2n7t" style="background-color:#fffaf0;"></div>
-[[Category: Unreleased Structures]]
+== References ==
-[[Category: Novellino, E]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Brancaccio, D]]
+[[Category: Carotenuto, A]]
+[[Category: Chai, M]]
 [[Category: Grieco, P]]
-[[Category: Brancaccio, D]]
 [[Category: Hruby, V]]
+[[Category: Merlino, F]]
+[[Category: Novellino, E]]
 [[Category: Yousif, A]]
-[[Category: Carotenuto, A]]
+[[Category: De novo protein]]
-[[Category: Merlino, F]]
-[[Category: Chai, M]]