4qob: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4qob is ~~ON HOLD until Paper Publication~~

==Crystal structure of cPOP1==

~~Authors~~: ~~Park~~, H.H.

== Structural highlights ==

<table><tr><td colspan='2'>[[4qob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QOB FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~cPOP1~~

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYDC1, ASC2, ASCI, POP1, PYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qob OCA], [http://pdbe.org/4qob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qob RCSB], [http://www.ebi.ac.uk/pdbsum/4qob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qob ProSAT]</span></td></tr>

[[Category: Park, H.H]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PYDC1_HUMAN PYDC1_HUMAN]] Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.<ref>PMID:12656673</ref> <ref>PMID:24871464</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Human]]

[[Category: Large Structures]]

[[Category: Park, H H]]

[[Category: Death domain superfamily]]

[[Category: Protein binding]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4qob is ON HOLD  until Paper Publication
+==Crystal structure of cPOP1==
+<StructureSection load='4qob' size='340' side='right'caption='[[4qob]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors: Park, H.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4qob]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QOB FirstGlance]. <br>
-Description: Crystal structure of cPOP1
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYDC1, ASC2, ASCI, POP1, PYC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qob OCA], [http://pdbe.org/4qob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qob RCSB], [http://www.ebi.ac.uk/pdbsum/4qob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qob ProSAT]</span></td></tr>
-[[Category: Park, H.H]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PYDC1_HUMAN PYDC1_HUMAN]] Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.<ref>PMID:12656673</ref> <ref>PMID:24871464</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Human]]
+[[Category: Large Structures]]
+[[Category: Park, H H]]
+[[Category: Death domain superfamily]]
+[[Category: Protein binding]]