4zp5: Difference between revisions
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==MAP4K4 in complex with inhibitor== | |||
<StructureSection load='4zp5' size='340' side='right' caption='[[4zp5]], [[Resolution|resolution]] 2.29Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zp5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZP5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4QG:4-[5-(4-CHLOROPHENYL)-1,3-OXAZOL-2-YL]BENZAMIDE'>4QG</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zp5 OCA], [http://pdbe.org/4zp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zp5 RCSB], [http://www.ebi.ac.uk/pdbsum/4zp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zp5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/M4K4_HUMAN M4K4_HUMAN]] Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.<ref>PMID:9890973</ref> <ref>PMID:21690388</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Non-specific serine/threonine protein kinase]] | |||
[[Category: Liu, S]] | [[Category: Liu, S]] | ||
[[Category: Inhibitor]] | |||
[[Category: Kinase]] | |||
[[Category: Transferase-inhibitor complex]] | |||
