5aod: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5aod is ~~ON HOLD~~

==Crystal structure of wild type pneumolysin.==

~~Authors~~: ~~van Pee~~, K., ~~Yildiz~~, O.

== Structural highlights ==

<table><tr><td colspan='2'>[[5aod]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOD FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of ~~wild type pneumolysin~~.

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aoe|5aoe]], [[5aof|5aof]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aod OCA], [http://pdbe.org/5aod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aod RCSB], [http://www.ebi.ac.uk/pdbsum/5aod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aod ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).

__TOC__

</StructureSection>

[[Category: Pee, K van]]

[[Category: Yildiz, O]]

[[Category: ~~Van Pee, K~~]]

[[Category: Cholesterol dependent cytolysin]]

[[Category: Pore forming toxin]]

[[Category: Toxin]]

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-'''Unreleased structure'''
-The entry 5aod is ON HOLD
+==Crystal structure of wild type pneumolysin.==
+<StructureSection load='5aod' size='340' side='right' caption='[[5aod]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: van Pee, K., Yildiz, O.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5aod]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AOD FirstGlance]. <br>
-Description: Crystal structure of wild type pneumolysin.
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aoe|5aoe]], [[5aof|5aof]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aod OCA], [http://pdbe.org/5aod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5aod RCSB], [http://www.ebi.ac.uk/pdbsum/5aod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5aod ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Pee, K van]]
 [[Category: Yildiz, O]]
-[[Category: Van Pee, K]]
+[[Category: Cholesterol dependent cytolysin]]
+[[Category: Pore forming toxin]]
+[[Category: Toxin]]