5ay3: Difference between revisions
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''' | ==Crystal structure of RNA duplex containing C-C base pairs== | ||
<StructureSection load='5ay3' size='340' side='right' caption='[[5ay3]], [[Resolution|resolution]] 1.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ay3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AY3 FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ay3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay3 OCA], [http://pdbe.org/5ay3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ay3 RCSB], [http://www.ebi.ac.uk/pdbsum/5ay3 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Metallo-base pairs have been extensively studied for applications in nucleic acid-based nanodevices and genetic code expansion. Metallo-base pairs composed of natural nucleobases are attractive because nanodevices containing natural metallo-base pairs can be easily prepared from commercially available sources. Previously, we have reported a crystal structure of a DNA duplex containing THgII T base pairs. Herein, we have determined a high-resolution crystal structure of the second natural metallo-base pair between pyrimidine bases CAgI C formed in an RNA duplex. One AgI occupies the center between two cytosines and forms a CAgI C base pair through N3AgI N3 linear coordination. The CAgI C base pair formation does not disturb the standard A-form conformation of RNA. Since the CAgI C base pair is structurally similar to the canonical Watson-Crick base pairs, it can be a useful building block for structure-based design and fabrication of nucleic acid-based nanodevices. | |||
High-Resolution Crystal Structure of Silver(I)-RNA Hybrid Duplex Containing Watson-Crick-like CSilver(I)C Metallo-Base Pairs.,Kondo J, Tada Y, Dairaku T, Saneyoshi H, Okamoto I, Tanaka Y, Ono A Angew Chem Int Ed Engl. 2015 Oct 8. doi: 10.1002/anie.201507894. PMID:26448329<ref>PMID:26448329</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5ay3" style="background-color:#fffaf0;"></div> | |||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dairaku, T]] | |||
[[Category: Kondo, J]] | [[Category: Kondo, J]] | ||
[[Category: Okamoto, I]] | [[Category: Okamoto, I]] | ||
[[Category: Ono, A]] | [[Category: Ono, A]] | ||
[[Category: Saneyoshi, H]] | [[Category: Saneyoshi, H]] | ||
[[Category: | [[Category: Tada, Y]] | ||
[[Category: Tanaka, Y]] | [[Category: Tanaka, Y]] | ||
[[Category: Metallo base pair]] | |||
[[Category: Rna]] | |||
[[Category: X-ray analysis]] | |||
Revision as of 05:25, 22 October 2015
Crystal structure of RNA duplex containing C-C base pairs
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