5do9: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q==

~~The entry~~ 5do9 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5do9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DO9 FirstGlance]. <br>

~~Authors~~: ~~Taylor~~, V.G., ~~Tesmer~~, J.J.G.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5do9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do9 OCA], [http://pdbe.org/5do9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5do9 RCSB], [http://www.ebi.ac.uk/pdbsum/5do9 PDBsum]</span></td></tr>

~~Description~~: ~~Structure~~ of ~~regulator~~ of G protein ~~signaling 8~~ (~~RGS8~~) ~~in complex with AlF4~~-~~activated Galpha~~-q

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[Category: Tesmer, J.J.G]]

[[http://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> [[http://www.uniprot.org/uniprot/RGS8_HUMAN RGS8_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).

[[Category: ~~Taylor, V.G~~]]

== References ==

__TOC__

</StructureSection>

[[Category: Taylor, V G]]

[[Category: Tesmer, J J.G]]

[[Category: Gq-g11]]

[[Category: Gtp-binding protein alpha subunit]]

[[Category: Protein binding]]

[[Category: Rgs protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q==
+<StructureSection load='5do9' size='340' side='right' caption='[[5do9]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-The entry 5do9 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5do9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DO9 FirstGlance]. <br>
-Authors: Taylor, V.G., Tesmer, J.J.G.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5do9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do9 OCA], [http://pdbe.org/5do9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5do9 RCSB], [http://www.ebi.ac.uk/pdbsum/5do9 PDBsum]</span></td></tr>
-Description: Structure of regulator of G protein signaling 8 (RGS8) in complex with AlF4-activated Galpha-q
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Tesmer, J.J.G]]
+[[http://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref>  [[http://www.uniprot.org/uniprot/RGS8_HUMAN RGS8_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity).
-[[Category: Taylor, V.G]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Taylor, V G]]
+[[Category: Tesmer, J J.G]]
+[[Category: Gq-g11]]
+[[Category: Gtp-binding protein alpha subunit]]
+[[Category: Protein binding]]
+[[Category: Rgs protein]]