5dof: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==Crystal structure of Tetrahymena p19==

== Structural highlights ==

<table><tr><td colspan='2'>[[5dof]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DOF FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5doi|5doi]], [[5dok|5dok]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dof OCA], [http://pdbe.org/5dof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dof RCSB], [http://www.ebi.ac.uk/pdbsum/5dof PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis.

The ~~entry 5dof~~ is ~~ON HOLD until Paper Publication~~

The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.,Wan B, Tang T, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J, Lei M Nat Struct Mol Biol. 2015 Nov 9. doi: 10.1038/nsmb.3126. PMID:26551074<ref>PMID:26551074</ref>

~~Authors: Wan~~, B.~~, Tang, T~~.~~, Wu, J., Lei, M~~.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description~~: ~~Crystal structure of Tetrahymena p19~~

~~[[Category: Unreleased Structures]]~~

== References ==

__TOC__

</StructureSection>

[[Category: Lei, M]]

[[Category: Tang, T]]

[[Category: Wan, B]]

[[Category: Wu, J]]

[[Category: ~~Tang, T~~]]

[[Category: Dna binding protein]]

[[Category: Ob fold]]

[[Category: Telomerase]]

[[Category: Tetrahymena]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of Tetrahymena p19==
+<StructureSection load='5dof' size='340' side='right' caption='[[5dof]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5dof]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DOF FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5doi|5doi]], [[5dok|5dok]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dof OCA], [http://pdbe.org/5dof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dof RCSB], [http://www.ebi.ac.uk/pdbsum/5dof PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Tetrahymena telomerase holoenzyme subunits p75, p45 and p19 form a subcomplex (7-4-1) peripheral to the catalytic core. We report structures of p45 and p19 and reveal them as the Stn1 and Ten1 subunits of the CST complex, which stimulates telomerase complementary-strand synthesis. 7-4-1 binds telomeric single-stranded DNA, and mutant p19 overexpression causes telomere 3'-overhang elongation. We propose that telomerase-tethered Tetrahymena CST coordinates telomere G-strand and C-strand synthesis.
-The entry 5dof is ON HOLD  until Paper Publication
+The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex.,Wan B, Tang T, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J, Lei M Nat Struct Mol Biol. 2015 Nov 9. doi: 10.1038/nsmb.3126. PMID:26551074<ref>PMID:26551074</ref>
-Authors: Wan, B., Tang, T., Wu, J., Lei, M.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Crystal structure of Tetrahymena p19
+<div class="pdbe-citations 5dof" style="background-color:#fffaf0;"></div>
-[[Category: Unreleased Structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Lei, M]]
+[[Category: Tang, T]]
 [[Category: Wan, B]]
 [[Category: Wu, J]]
-[[Category: Tang, T]]
+[[Category: Dna binding protein]]
+[[Category: Ob fold]]
+[[Category: Telomerase]]
+[[Category: Tetrahymena]]