5e1e: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Human JAK1 kinase in complex with compound 30 at 2.30 Angstroms resolution==

~~The entry~~ 5e1e is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5e1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1E OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E1E FirstGlance].

~~Authors~~: ~~Ferguson~~, A.D.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=5JG:6-CHLORO-2-(2-FLUORO-4,5-DIMETHOXYPHENYL)-N-(PIPERIDIN-4-YLMETHYL)-3H-IMIDAZO[4,5-B]PYRIDIN-7-AMINE'>5JG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>

~~Description~~:

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1e OCA], [http://pdbe.org/5e1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e1e RCSB], [http://www.ebi.ac.uk/pdbsum/5e1e PDBsum]</td></tr>

[[Category: Ferguson, A.D]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.

__TOC__

</StructureSection>

[[Category: Non-specific protein-tyrosine kinase]]

[[Category: Ferguson, A D]]

[[Category: Kinase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Human JAK1 kinase in complex with compound 30 at 2.30 Angstroms resolution==
+<StructureSection load='5e1e' size='340' side='right' caption='[[5e1e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-The entry 5e1e is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5e1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E1E FirstGlance]. <br>
-Authors: Ferguson, A.D.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5JG:6-CHLORO-2-(2-FLUORO-4,5-DIMETHOXYPHENYL)-N-(PIPERIDIN-4-YLMETHYL)-3H-IMIDAZO[4,5-B]PYRIDIN-7-AMINE'>5JG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-Description:
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e1e OCA], [http://pdbe.org/5e1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e1e RCSB], [http://www.ebi.ac.uk/pdbsum/5e1e PDBsum]</span></td></tr>
-[[Category: Ferguson, A.D]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
+__TOC__
+</StructureSection>
+[[Category: Non-specific protein-tyrosine kinase]]
+[[Category: Ferguson, A D]]
+[[Category: Kinase]]
+[[Category: Transferase]]