5e26: Difference between revisions
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''' | ==Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate== | ||
<StructureSection load='5e26' size='340' side='right' caption='[[5e26]], [[Resolution|resolution]] 2.14Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5e26]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E26 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E26 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PAU:PANTOTHENOIC+ACID'>PAU</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e26 OCA], [http://pdbe.org/5e26 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e26 RCSB], [http://www.ebi.ac.uk/pdbsum/5e26 PDBsum]</span></td></tr> | |||
[[ | </table> | ||
[[ | == Disease == | ||
[[ | [[http://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN]] Atypical pantothenate kinase-associated neurodegeneration;Classic pantothenate kinase-associated neurodegeneration. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/PANK2_HUMAN PANK2_HUMAN]] May be the master regulator of the CoA biosynthesis. | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Pantothenate kinase]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: BROWN, P J]] | |||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
[[Category: | [[Category: CHENG, C]] | ||
[[Category: | [[Category: DONG, A]] | ||
[[Category: | [[Category: Edwards, A M]] | ||
[[Category: | [[Category: HONG, B S]] | ||
[[Category: | [[Category: HUTCHINSON, A]] | ||
[[Category: | [[Category: LOPPNAU, P]] | ||
[[Category: Structural | [[Category: RAVICHANDRAN, M]] | ||
[[Category: SEITOVA, A]] | |||
[[Category: Structural genomic]] | |||
[[Category: TEMPEL, W]] | |||
[[Category: Pank2]] | |||
[[Category: Sgc]] | |||
[[Category: Transferase]] | |||
Revision as of 05:34, 22 October 2015
Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate
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