2n8a: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==NMR solution structure and assignments==

~~The entry~~ 2n8a is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[2n8a]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N8A OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N8A FirstGlance].

~~Authors~~: ~~Neuhaus~~, D., ~~Eustermann~~, S., ~~Yang~~, J., Wu, W.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </td></tr>

~~Description~~:

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n8a OCA], [http://pdbe.org/2n8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n8a RCSB], [http://www.ebi.ac.uk/pdbsum/2n8a PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Eustermann, S]]

[[Category: Neuhaus, D]]

[[Category: Wu, W]]

[[Category: Yang, J]]

[[Category: ~~Neuhaus, D]]~~

[[Category: Transferase]]

~~[[Category: Eustermann, S~~]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==NMR solution structure and assignments==
+<StructureSection load='2n8a' size='340' side='right' caption='[[2n8a]], [[NMR_Ensembles_of_Models | 78 NMR models]]' scene=''>
-The entry 2n8a is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2n8a]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N8A FirstGlance]. <br>
-Authors: Neuhaus, D., Eustermann, S., Yang, J., Wu, W.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-Description:
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n8a OCA], [http://pdbe.org/2n8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n8a RCSB], [http://www.ebi.ac.uk/pdbsum/2n8a PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+{{Large structure}}
+== Function ==
+[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Eustermann, S]]
+[[Category: Neuhaus, D]]
 [[Category: Wu, W]]
 [[Category: Yang, J]]
-[[Category: Neuhaus, D]]
+[[Category: Transferase]]
-[[Category: Eustermann, S]]