5e8f: Difference between revisions
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''' | ==Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D== | ||
<StructureSection load='5e8f' size='340' side='right' caption='[[5e8f]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5e8f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E8F FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GER:GERAN-8-YL+GERAN'>GER</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8f OCA], [http://pdbe.org/5e8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8f RCSB], [http://www.ebi.ac.uk/pdbsum/5e8f PDBsum]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Ismail, S. | == Disease == | ||
[[http://www.uniprot.org/uniprot/PDE6C_HUMAN PDE6C_HUMAN]] Progressive cone dystrophy;Achromatopsia. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: 3',5'-cyclic-GMP phosphodiesterase]] | |||
[[Category: Fansa, E K]] | |||
[[Category: Ismail, S A]] | |||
[[Category: Reilly, N J.O]] | |||
[[Category: Wittinghofer, A]] | [[Category: Wittinghofer, A]] | ||
[[Category: | [[Category: Geranylgeranyl]] | ||
[[Category: Hydrolase]] | |||
[[Category: Immunoglobulin-like beta sandwitch fold]] | |||
[[Category: Prenyl binding protein]] | |||
Revision as of 19:01, 1 December 2015
Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D
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