Aconitase: Difference between revisions

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:citrate = aconitate + H<sub>2</sub>O = L-isocitrate
:citrate = aconitate + H<sub>2</sub>O = L-isocitrate
This reaction is part of the citrate (TCA-, Krebs-)cycle.
This reaction is part of the citrate (TCA-, Krebs-)cycle.
The image at at the right corresponds to one representative Aconitase, ''i.e.'' the crystal structure of Bovine Aconitase ([[1amj]]).
In most organisms, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria.
In most organisms, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria.
Aconitase contains a Fe4S4 cluster which converts to Fe3S4 when the enzyme is inactive.  In humans, two types of ACO are expressed: the soluble '''ACO1''' and the mitochondrial '''ACO2'''.
Aconitase contains a Fe4S4 cluster which converts to Fe3S4 when the enzyme is inactive.  In humans, two types of ACO are expressed: the soluble '''ACO1''' and the mitochondrial '''ACO2'''.
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