Aconitase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='' size=' | <StructureSection load='' size='350' side='right' scene='Aconitase/Cv/1' caption='Bovine aconitase showing FeS4 cluster complex with sulfate (PDB code [[1amj]])'> | ||
==Function== | ==Function== | ||
| Line 8: | Line 8: | ||
In most organisms, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria. | In most organisms, there is a cytosolic enzyme with an ACO domain (cAc), and in eukaryotes, a second copy of it was introduced with mitochondria (mAc). Plants developed even more copies in mitochondria. | ||
Aconitase contains a Fe4S4 cluster which converts to Fe3S4 when the enzyme is inactive. In humans, two types of ACO are expressed: the soluble '''ACO1''' and the mitochondrial '''ACO2'''. | Aconitase contains a Fe4S4 cluster which converts to Fe3S4 when the enzyme is inactive. In humans, two types of ACO are expressed: the soluble '''ACO1''' and the mitochondrial '''ACO2'''. | ||
Aconitase from pig (PDB [[7acn]]) is a single polypeptide (M<sub>r</sub> 83kD) that catalyzes the reversible isomerization of citrate and isocitrate.<ref name="Zheng">PMID 1313811</ref> It is the second enzyme in the Citric acid cycle, which is a series of enzyme-catalysed chemical reactions that is crucial to aerobic cellular respiration and the production of ATP. | Aconitase from pig (PDB [[7acn]]) is a single polypeptide (M<sub>r</sub> 83kD) that catalyzes the reversible isomerization of citrate and isocitrate.<ref name="Zheng">PMID 1313811</ref> It is the second enzyme in the Citric acid cycle, which is a series of enzyme-catalysed chemical reactions that is crucial to aerobic cellular respiration and the production of ATP. See also:<br /> | ||
*[[Krebs cycle carbons]] | |||
*[[Krebs cycle importance]] | |||
*[[Krebs cycle overview]] | |||
*[[Krebs cycle step 2]] | |||
==Structure== | ==Structure== | ||
