Sandbox Reserved 988: Difference between revisions
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{{Sandbox_gvsu_chm463}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_gvsu_chm463}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==Your Heading Here (maybe something like 'Structure')== | ==Your Heading Here (maybe something like 'Structure')== | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Background == | |||
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== History == | == History == | ||
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With myth-like reverence, medical textbooks recount Alexander Flemming’s serendipitous observation of the antibacterial action of Penicillium mold in 1928. While not the first to note the inhibitory effect, Flemming became the first to seriously push the scientific community to research the isolation of the active compound, which he named penicillin. Eventually these efforts paid off, and in 1940, Sir Ernst Boris Chain published a method of isolating and purifying penicillin and tested its clinical effectiveness in mice. In the same year, he identified the first β-lactamase in Escherichia coli. They published their findings in a letter to the journal Nature titled, “An Enzyme from Bacteria able to Destroy Penicillin.” While interesting, this discovery was not considered clinically relevant until β-lactamase enzymes were isolated from clinical samples of gram positive bacteria by Dr. William M. M. Kirby | With myth-like reverence, medical textbooks recount Alexander Flemming’s serendipitous observation of the antibacterial action of Penicillium mold in 1928. While not the first to note the inhibitory effect, Flemming became the first to seriously push the scientific community to research the isolation of the active compound, which he named penicillin. Eventually these efforts paid off, and in 1940, Sir Ernst Boris Chain published a method of isolating and purifying penicillin and tested its clinical effectiveness in mice. In the same year, he identified the first β-lactamase in Escherichia coli. They published their findings in a letter to the journal Nature titled, “An Enzyme from Bacteria able to Destroy Penicillin.” While interesting, this discovery was not considered clinically relevant until β-lactamase enzymes were isolated from clinical samples of gram positive bacteria by Dr. William M. M. Kirby | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | |||
== | == Structural Highlights == | ||
== | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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== Mechanism == | |||
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== | == Inhibition == | ||
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</StructureSection> | </StructureSection> | ||
== Disease == | |||
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== References == | == References == | ||
<references/> | <references/> | ||
