Arrestin: Difference between revisions

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<StructureSection load='2wtr' size='340' side='right' caption='Bovine arrestin-2 complex with Ba+2 ions (PDB code [[2wtr]])' scene=''>
<StructureSection load='2wtr' size='340' side='right' caption='Bovine arrestin-2 complex with Ba+2 ions (PDB code [[2wtr]])' scene=''>
'''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation.  ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways.  Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.


== Function ==
== Function ==


== Disease ==
'''Arrestin''' (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation.  ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways.  Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions.


== Relevance ==
== Structural highlights ==


== Structural highlights ==
ARR consist of 2 domains.  The N terminal domain structure is immunoglobulin-like.  The binding site of phosphorylated light-activated rhodopsin is located at the N terminal of ARR.


</StructureSection>
</StructureSection>
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