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| '''Azurin''' (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center. | | '''Azurin''' (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center. |
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| == Disease ==
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| == Relevance == | | == Relevance == |
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| AZ was found to be a novel anticancer agent. Following the entry of the ''P. aeruginosa'' bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells. | | AZ was found to be a novel anticancer agent. Following the entry of the ''P. aeruginosa'' bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells. |
| </StructureSection>
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| == Structural highlights == | | == Structural highlights == |
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| AZ active Cu binding site is shown here. | | AZ active Cu binding site is shown here. |
| | | </StructureSection> |
| ==3D structures of cAMP-dependent protein kinase== | | ==3D structures of cAMP-dependent protein kinase== |
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Revision as of 11:58, 8 November 2015
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Function
Azurin (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.
Relevance
AZ was found to be a novel anticancer agent. Following the entry of the P. aeruginosa bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.
Structural highlights
AZ active Cu binding site is shown here.
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3D structures of cAMP-dependent protein kinase
Updated on 08-November-2015
{"openlevels":0}
- Azurin
- 1e65 – PaAZ – Pseudomonas aeruginosa
- Cu+2 containing azurin
- 1azu, 1azr, 4azu, 5azu, 1azn, 1cc3, 1e5y, 1e5z, 1jze, 2ft6, 2ft7, 2ft8, 2fta, 3fs9, 3fsa, 3fsv, 3fsw, 3fsz, 3ft0 – PaAZ
- 3fq2, 4hip, 4qkt – PaAZ (mutant)
- 1cuo, 1uat – AZ – Methylomonas
- 1joi – PfAZ – Pseudomonas fluorrescens
- 1nwo – PpAZ – Pseudomonas putida
- 1nwp – PpAZ + Zn+2
- 2aza, 1azb, 1azc, 1rkr – AxAZ – Achromobacter xylosoxidans
- 1dyz, 1dz0, 2ccw – AZ II – Alcaligenes xylosoxidans
- 2azu, 3azu, 1ils, 1ilu, 2tsa, 2tsb, 1etj, 1ag0, 1ezl, 1jvo, 1gr7, 1xb3, 1xb6, 1xb8, 2ghz, 2hx7, 2oj1, 3in0, 3fpy, 3fq1, [3fq2]], 3fqy, 3in2, 3jt2, 3jtb, 3np3, 3np4, 3oqr, 3n2j, 3u25, 4hhw, 4mfh, 4ko5, 4ko6, 4ko7, 4ko9, 4kob, 4koc, 4bww – PaAZ (mutant)
- 1jvl, 2idf – PaAZ (mutant) + Ni+2
- 1uri, 1a4a, 1a4b, 1a4c – AdAZ (mutant)
- 2h3x, 2h47, 2iaa – AZ + aromatic amine dehydrogenase – Alcaligenes faecalis
- Cu+2 containing lanthanide-modified azurin
- 1bex, 1jzi, 1jze, 1jzf, 1jzj, 1jzh – PaAZ
- 2i7s, 2fnw, 2i7o, 3ibo, 4hhg, 4k9j – PaAZ (mutant)
- Cu+1 containing azurin
- Other metals-containing azurin
- 1aiz – AdAZ + Cd+2 – Achromobacter denitrificans
- 1nzr – PaAZ (mutant) + Ni+2
- 1vlx – PaAZ + Co+2
- 1e67 – PaAZ + Zn+2
- 2iwe – PaAZ (mutant) + Zn+2
- 3ay2 – AZ (mutant) + Zn+2 – Neisseria Gonorhoeae
- 3uge – PaAZ + Ag+1
- 4hz1 – PaAZ + Fe+2
- 4qlw – PaAZ (mutant) + Fe+2
- 4jkn – PaAZ + Hg+2
References
