Sandbox8999: Difference between revisions
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== Structure == | == Structure == | ||
An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.1 The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.1 The aforementioned zig-zags are what create the “leg” looking structure of the triskelion. 1 Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals. The heavy chain and light chain bind through one long alpha helix towards the center of the protein. 1 | An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.1 The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.1 The aforementioned zig-zags are what create the “leg” looking structure of the triskelion. 1 Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals. The heavy chain and light chain bind through one long alpha helix towards the center of the protein. 1 [[Image:Clathrin-Cage.jpg]] | ||
== Function == | == Function == | ||
