Sandbox8999: Difference between revisions
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The formation of most cellular vesicles are facilitated by coat-proteins like clathrin.<ref name ="johnson"> Johnson, G. T., & Goodsell, D. (2007). Molecule of the Month: Clathrin. [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 doi: 10.2210/rcsb_pdb/mom_2007_4]</ref> Endocytic events are initiated through the activity of the clathrin coat and adaptor proteins that select the “cargo” that will be carried into the cell in vesicles.<ref name="mcpherson"> McPherson, P. S., Ritter, B., & Wendland, B. Clathrin-Mediated Endocytosis. (2009). Clathrin-Mediated Endocytosis. In Trafficking Inside Cells: Pathways, Mechanisms, and Regulation (Section II). [http://dx.doi.org/10.1007/978-0-387-93877-6_9 doi: 10.1007/978-0-387-93877-6_9]</ref> Cells endocytose vesicles from the plasma membrane to perform housekeeping tasks such as taking up nutrients, importing signaling receptors, mediating immune responses, cleaning up cell debris, or providing a pathway for pathogens or toxins.<ref name="johnson" /> | The formation of most cellular vesicles are facilitated by coat-proteins like clathrin.<ref name ="johnson"> Johnson, G. T., & Goodsell, D. (2007). Molecule of the Month: Clathrin. [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 doi: 10.2210/rcsb_pdb/mom_2007_4]</ref> Endocytic events are initiated through the activity of the clathrin coat and adaptor proteins that select the “cargo” that will be carried into the cell in vesicles.<ref name="mcpherson"> McPherson, P. S., Ritter, B., & Wendland, B. Clathrin-Mediated Endocytosis. (2009). Clathrin-Mediated Endocytosis. In Trafficking Inside Cells: Pathways, Mechanisms, and Regulation (Section II). [http://dx.doi.org/10.1007/978-0-387-93877-6_9 doi: 10.1007/978-0-387-93877-6_9]</ref> Cells endocytose vesicles from the plasma membrane to perform housekeeping tasks such as taking up nutrients, importing signaling receptors, mediating immune responses, cleaning up cell debris, or providing a pathway for pathogens or toxins.<ref name="johnson" /> | ||
There are various endocytic mechanisms by which eukaryotic cells bring proteins and lipids into the cell, however clathrin-mediated endocytosis is known to be the most informative pathway to date. Other portals for endocytic entry include phagocytosis and macropinocytosis.<ref name="mcpherson"> McPherson, P. S., Ritter, B., & Wendland, B. Clathrin-Mediated Endocytosis. (2009). Clathrin-Mediated Endocytosis. In Trafficking Inside Cells: Pathways, Mechanisms, and Regulation (Section II). [http://dx.doi.org/10.1007/978-0-387-93877-6_9 doi: 10.1007/978-0-387-93877-6_9]</ref> Endocytic events are initiated through the activity of the clathrin coat and adaptor proteins that select the “cargo” that will be carried into the cell in vesicles.<ref name ="johnson"> Johnson, G. T., & Goodsell, D. (2007). Molecule of the Month: Clathrin. [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 doi: 10.2210/rcsb_pdb/mom_2007_4]</ref> At least 20 clathrin adaptors have been identified, and they all recognize and bind to membrane proteins or phospholipids that are specific for a certain organelle.<ref name ="johnson"> Johnson, G. T., & Goodsell, D. (2007). Molecule of the Month: Clathrin. [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 doi: 10.2210/rcsb_pdb/mom_2007_4]</ref> The formation of most cellular vesicles are facilitated by these coat-proteins like clathrin.<ref name ="johnson"> Johnson, G. T., & Goodsell, D. (2007). Molecule of the Month: Clathrin. [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 doi: 10.2210/rcsb_pdb/mom_2007_4]</ref> Cells endocytose vesicles from the plasma membrane to perform housekeeping tasks such as taking up nutrients, importing signaling receptors, mediating immune responses, cleaning up cell debris, or providing a pathway for pathogens or toxins.<ref name ="johnson"> Johnson, G. T., & Goodsell, D. (2007). Molecule of the Month: Clathrin. [http://dx.doi.org/10.2210/rcsb_pdb/mom_2007_4 doi: 10.2210/rcsb_pdb/mom_2007_4]</ref> | |||
'''The Canonical and Noncanonical Pathway''' | '''The Canonical and Noncanonical Pathway''' | ||
