Sandbox8999: Difference between revisions
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Individual clathrin molecules can assemble into cage-like structures. When individual clathrin molecules come together, a lattice is formed where each lattice point is associated with the center of a triskelion (from the Greek word meaning “a three legged structure”). <ref name="harrison" /> | Individual clathrin molecules can assemble into cage-like structures. When individual clathrin molecules come together, a lattice is formed where each lattice point is associated with the center of a triskelion (from the Greek word meaning “a three legged structure”). <ref name="harrison" /> | ||
[[Image:Clathrin-Cage.jpg |frame|]] | [[Image:Clathrin-Cage.jpg |frame|]] Formation of clathrin lattice from individual clathrin monomers. | ||
Formation of clathrin lattice from individual clathrin monomers. | |||
== Function == | == Function == | ||
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The '''noncanonical clathrin pathway''' refers to clathrin-actin assemblies, which form phagocytotic vesicles in response to invading bacterium.<ref name="harrison" /> Pathogen invasion into nonphagocytic cells result in the recruitment of clathrin.<ref name="harrison" /> These pathogens invade the cell through a process called the “zippering” mechanism, in which actin filaments are utilized to surround the pathogens with the host-cell membrane.<ref name="harrison" /> Actin recruitment requires the formation of clathrin patches and thus the clathrin-assembly forms.<ref name="harrison" /> Actin is not usually needed in classical endocytosis, but it is required when the size of the cargo in the forming vesicle is too large for the vesicle to close.<ref name="harrison" /> This association between actin and clathrin is unique to this pathway and distinguishes the noncanonical from the canonical pathway.<ref name="harrison" /> | The '''noncanonical clathrin pathway''' refers to clathrin-actin assemblies, which form phagocytotic vesicles in response to invading bacterium.<ref name="harrison" /> Pathogen invasion into nonphagocytic cells result in the recruitment of clathrin.<ref name="harrison" /> These pathogens invade the cell through a process called the “zippering” mechanism, in which actin filaments are utilized to surround the pathogens with the host-cell membrane.<ref name="harrison" /> Actin recruitment requires the formation of clathrin patches and thus the clathrin-assembly forms.<ref name="harrison" /> Actin is not usually needed in classical endocytosis, but it is required when the size of the cargo in the forming vesicle is too large for the vesicle to close.<ref name="harrison" /> This association between actin and clathrin is unique to this pathway and distinguishes the noncanonical from the canonical pathway.<ref name="harrison" /> | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
