Sandbox 77: Difference between revisions
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== Structural highlights/Specific Function == | == Structural highlights/Specific Function == | ||
5-HT1B: This receptor couples to G-protein alpha subunits Gi and Go. In the central nervous system, this receptor is an inhibitory presynaptic receptor that can alter the release of serotonin, as well as other neurotransmitters, from the presynaptic neuron. The structure of this receptor includes 7 transmembrane alpha-helices in its center. The N-terminal tail of 5-HT1B is close to the ligand binding pocket suggesting some interaction with its ligand. The orthosteric, unmodulated, binding pocket is characterized as a cavity formed from residues of the 3rd, 5th, 6th, and 7th alpha helices and the 2nd extracellular loop. (Wang, et al. 2013) | 5-HT1B: This receptor couples to G-protein alpha subunits Gi and Go. In the central nervous system, this receptor is an inhibitory presynaptic receptor that can alter the release of serotonin, as well as other neurotransmitters, from the presynaptic neuron. The structure of this receptor includes 7 transmembrane alpha-helices in its center. The N-terminal tail of 5-HT1B is close to the ligand binding pocket suggesting some interaction with its ligand. The orthosteric, unmodulated, binding pocket is characterized as a cavity formed from residues of the 3rd, 5th, 6th, and 7th alpha helices and the 2nd extracellular loop. (Wang, et al. 2013) | ||
[[Image:4IAR.jpg]] | |||
5-HT2B: This receptor is important in utilizing serotonin signals to encourage proper development and continuing function of the cardiovascular system. Overexpression of 5-HT2B has been linked to congestive heart failure. (Janssen, et al. 2015) 5-HT2B utilizes the alpha Gq protein pathway which triggers intracellular cGMP production through activation of nictric-oxidase synthase (NOS). (Nebigil, et al. 2001) This receptor is also known for being the target of the drug LSD, which has similar structure to serotonin. (Berumen, et al. 2012) The structure of this receptor is much like that of 5-HT1B. It has the characteristic 7 alpha helices and the N-terminus sticks out into extracellular space. (Wang, et al. 2013) | 5-HT2B: This receptor is important in utilizing serotonin signals to encourage proper development and continuing function of the cardiovascular system. Overexpression of 5-HT2B has been linked to congestive heart failure. (Janssen, et al. 2015) 5-HT2B utilizes the alpha Gq protein pathway which triggers intracellular cGMP production through activation of nictric-oxidase synthase (NOS). (Nebigil, et al. 2001) This receptor is also known for being the target of the drug LSD, which has similar structure to serotonin. (Berumen, et al. 2012) The structure of this receptor is much like that of 5-HT1B. It has the characteristic 7 alpha helices and the N-terminus sticks out into extracellular space. (Wang, et al. 2013) | ||
