703DSS

The structure and function of the 5-HT3 receptor

spinqualitylabelsall models 5-HT3a receptor Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D This is a default text for your page Julio Soriagalvarro/Sandbox703. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia or to the article describing Jmol to the rescue. Function This receptor plays a role in multiple processes throughout the brain and gastrointestinal tract. First, this receptor is responsible for altering anxiety levels. Research has indicated that several 5-HT3 antagonists are responsible for lowering anxiety. These antagonists prevent serotonin from binding to the receptor and increase the level of serotonin in the synapse, ultimately lowering anxiety levels (Kurhe, Radhakrishnan, Thangaraj, & Gupta, 2014). Second, these receptors play a role in emesis. These receptors can be found at the end of the vagus nerve located in the digestive tract, and when serotonin binds there is a stimulation of the vomiting reflex causing individuals to become ill (“Serotonin - Receptors and effects”). Finally, 5-HT3 receptors are bound to mucosal endings in the stomach and upon their activation can trigger motor neurons found in the intestine (Galligan, 2002). Depending on what the function of the motor neurons are, processes like secretion and peristalsis can be altered. As previously mentioned this receptor has both extracellular and transmembrane domains, each serving a different function. The extracellular domain operates through ligand binding in which competitive inhibitors can bind and interfere with carrying out the functions mentioned. The transmembrane domain serves to help with ion selectivity and electrical conductance and if altered can also affect signaling of any of the processes mentioned (Thompson & Lummis, 2006). Structural highlights This is a sample scene created with SAT to color by Group, and another to make a transparent representation of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

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Julio Soriagalvarro