Sandbox8999: Difference between revisions
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An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.<ref name="harrison" /> The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.<ref name="harrison" /> The aforementioned zig-zags are what create the “leg” looking structure of the triskelion.<ref name="harrison" /> Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals. The heavy chain and light chain bind through one long alpha helix towards the center of the protein.<ref name="harrison" /> | An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.<ref name="harrison" /> The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.<ref name="harrison" /> The aforementioned zig-zags are what create the “leg” looking structure of the triskelion.<ref name="harrison" /> Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals. The heavy chain and light chain bind through one long alpha helix towards the center of the protein.<ref name="harrison" /> | ||
[[Image:LatticeStructure.png |frame| a) Clathrin monomer with labeled heavy and light chains b) Clathrin monomers forming a basic lattice structure <ref name="pearse">PMID: 1063406</ref>]] | [[Image:LatticeStructure.png |frame| a) Clathrin monomer with labeled heavy and light chains b) Clathrin monomers forming a basic lattice structure. Clathrin is made of individual triskelion components that come together to form the cage-like structure of clathrin. Each vertex is composed of a triskelion leg. Although there are various packing models for clathrin cage assembly, the overall theme is multiple triskelions coming together to form the cage like structure.<ref name="pearse">PMID: 1063406</ref>]] | ||
===Lattice=== | ===Lattice=== | ||
