Caspase: Difference between revisions
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<StructureSection load='1pyo' size='450' side='right' scene='' caption='CASP-2 subunit P18 (grey, pink) and subunit P12 (green, yellow) complex with polypeptide inhibitor (magenta, cyan), aspartic aldehyde and acetyl group, [[1pyo]]'> | |||
'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.<br /> | '''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.<br /> | ||
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* '''CASP-9''' is an aspartic protease linked to mitochondrial death pathway. See [[Molecular Playground/Caspase-9 Regulation]].<br /> | * '''CASP-9''' is an aspartic protease linked to mitochondrial death pathway. See [[Molecular Playground/Caspase-9 Regulation]].<br /> | ||
* '''Metacaspase''' (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi. | * '''Metacaspase''' (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi. | ||
</StructureSection> | |||
==3D structures of caspase== | ==3D structures of caspase== | ||
