Cluster of Differentiation CD38

<StructureSection load='3gc6' size='450' side='right' scene= caption='Glycosylated Cluster of Differentiation 38 (CD38) complex with sulfate 3gc6'

Function

Cluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca+2 signaling. ADP-ribosyl cyclase (ADPRC) is the Aplysia californica homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR).

Relevance

CD38 is used as a marker for cell activation and for leukemia.

</StructureSection>

3D Structures of Cluster of Differentiation 38

Updated on 24-November-2015

{"openlevels":0}

• CD38
  • 3gc6 – bCD38 - bovine
    
  • 3gh3, 3ghh – bCD38 residues 32-278
    
  • 2eg9 - CD38 enzymatic domain (mutant) – mouse
    
  • 2ef1 - hCD38 enzymatic domain – human
    
  • 1yh3 - hCD38 enzymatic domain (mutant)
    
  • 1zvm - hCD38 (mutant)
    
  • 1isf – hADPRC2 (mutant)
    
• CD38+ligand
  • 3i9m, 3i9n – hCD38 enzymatic domain+ADPR analog
    
  • 3f6y – hCD38 enzymatic domain+Ca++
    
  • 3dzf - hCD38 enzymatic domain+intermediate
    
  • 3dzg - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex
    
  • 3dzh - hCD38 enzymatic domain (mutant)+GTP
    
  • 3dzi - hCD38 enzymatic domain (mutant)+intermediate/GTP complex
    
  • 3dzj, 3dzk - hCD38 enzymatic domain (mutant)+NMN complex
    
  • 2pgj, 2pgl - hCD38 enzymatic domain (mutant)+substrate analog
    
  • 2o3t - hCD38 enzymatic domain (mutant)+cGDPR
    
  • 3u4h, 3u4i - hCD38 enzymatic domain (mutant)+cIDPR
    
  • 2o3u - hCD38 enzymatic domain (mutant)+NGD
    
  • 2o3q, 2o3r, 2o3s - hCD38 enzymatic domain (mutant)+cADPR
    
  • 4f45 - hCD38 enzymatic domain (mutant)+ NAADP
    
  • 4f46 - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP
    
  • 4cmh - hCD38 enzymatic domain + antibody
    
  • 2i65 – hCD38+NAD
    
  • 3kou - hCD38+NAD derivative
    
  • 2i67 - hCD38 (mutant)+ADPR
    
  • 2hct - hCD38 enzymatic domain (mutant)+NMN
    
  • 3ofs - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR
    
  • 3raj - hCD38 enzymatic domain (mutant)+ FAB
    
  • 3rok, 3rom - hCD38 (mutant) + arabinitol derivative
    
  • 3roq - hCD38 (mutant) + hydrofuran derivative
    
  • 3rop - hCD38 (mutant) + arabinitol derivative + nicotinamide
    
  • 3p5s - bADPRC + arabinitol derivative
    
• ADPRC
  • 1r12 - AcADPRC - Aplysia californica
    
  • 1r0s – AcADPRC (mutant)
    
• ADPRC+ligand
  • 1r15 - AcADPRC+nicotinamide
    
  • 3i9j – AcADPRC+nicotinamide+2F-NAD+2F-ADPRI
    
  • 3i9k – AcADPRC (mutant)+NAD
    
  • 3i9l – AcADPRC (mutant)+N1-CIDPR
    
  • 3i9o – AcADPRC+Ribosyl-2F-ADPR
    
  • 3zwx, 3zwy – AcADPRC + 8-Br-ADPR
    
  • 1r16 - AcADPRC+3-pyridinylcarbinol
    
  • 3zwm – AcADPRC + NAD + cADPR
    
  • 3zwn – AcADPRC + NGD + cGDPR
    
  • 3zwo – AcADPRC + NGD + GDPR
    
  • 3zwp, 3zwv, 3zww – AcADPRC+ diphosphate ribosyl ara-2F-ADPR
    

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky