CD69: Difference between revisions
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<StructureSection load='3hup' size='350' side='right' caption='Structure of human CD69 C-type lectin-like domain dimer complex with Cl- (green) and Na+ (purple) ions (PDB entry [[3hup]])' scene='55/552187/Cv/1'> | <StructureSection load='3hup' size='350' side='right' caption='Structure of human CD69 C-type lectin-like domain dimer complex with Cl- (green) and Na+ (purple) ions (PDB entry [[3hup]])' scene='55/552187/Cv/1'> | ||
'''CD69''' ('''Cluster of Differentiation 69''') is a human transmembrane calcium-dependent lectin protein. CD69 functions as a signal-transmitting receptor in lymphocytes natural killer cells and platelets. CD69 expression is induced upon activation of T-cell lymphocytes. <scene name='55/552187/Cv/2'>Na ion binding site</scene> of CD69 C-type lectin-like domain dimer complex.<ref>PMID:20054122</ref> | '''CD69''' ('''Cluster of Differentiation 69''') is a human transmembrane calcium-dependent lectin protein. CD69 functions as a signal-transmitting receptor in lymphocytes natural killer cells and platelets. CD69 expression is induced upon activation of T-cell lymphocytes. <ref>PMID:11101293</ref> <scene name='55/552187/Cv/2'>Na ion binding site</scene> of CD69 C-type lectin-like domain dimer complex.<ref>PMID:20054122</ref> | ||
==3D structures of CD69== | ==3D structures of CD69== | ||
Revision as of 12:52, 29 November 2015
<StructureSection load='3hup' size='350' side='right' caption='Structure of human CD69 C-type lectin-like domain dimer complex with Cl- (green) and Na+ (purple) ions (PDB entry 3hup)' scene='55/552187/Cv/1'>
CD69 (Cluster of Differentiation 69) is a human transmembrane calcium-dependent lectin protein. CD69 functions as a signal-transmitting receptor in lymphocytes natural killer cells and platelets. CD69 expression is induced upon activation of T-cell lymphocytes. [1] Na ion binding site of CD69 C-type lectin-like domain dimer complex.[2]
3D structures of CD69
Updated on 29-November-2015
1e87, 1e8i, 1fm5, 3cck, 3hup – hCD69 C-type lectin-like domain – human
References
- ↑ Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. Biochemistry. 2000 Dec 5;39(48):14779-86. PMID:11101293
- ↑ Kolenko P, Skalova T, Vanek O, Stepankova A, Duskova J, Hasek J, Bezouska K, Dohnalek J. The high-resolution structure of the extracellular domain of human CD69 using a novel polymer. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt, 12):1258-60. Epub 2009 Nov 27. PMID:20054122 doi:10.1107/S1744309109043152
