4v0s: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by a 3-dehydroquinic acid derivative==

~~The entry~~ 4v0s is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4v0s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V0S OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V0S FirstGlance].

~~Authors~~: ~~Otero~~, ~~J.M.~~, ~~Llamas~~-~~Saiz~~, ~~A.L.~~, ~~Santiago~~, C., ~~Lamb~~, H., ~~Hawkins~~, A.R., ~~Maneiro~~, M.~~, Peon, A~~.~~, Gonzalez~~-~~Bello~~, C., ~~van Raaij~~, M.J.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2HN:(1R,2S,4S,5R)-2-(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL-1,4,5-TRIHYDROXY-3-OXOCYCLOHEXANE-1-CARBOXYLIC+ACID'>2HN</scene>, <scene name='pdbligand=7HN:3,4-DIHYDROXY-2-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]BENZOIC+ACID'>7HN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </td></tr>

~~Description~~: ~~Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by~~ a 3-~~dehydroquinic acid derivative~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v0s OCA], [http://pdbe.org/4v0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v0s RCSB], [http://www.ebi.ac.uk/pdbsum/4v0s PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Otero~~, ~~J.M~~]]

== Function ==

[[Category: Hawkins, A.R]]

[[http://www.uniprot.org/uniprot/AROQ_MYCTO AROQ_MYCTO]] Catalyzes a trans-dehydration via an enolate intermediate.

__TOC__

</StructureSection>

[[Category: 3-dehydroquinate dehydratase]]

[[Category: Gonzalez-Bello, C]]

[[Category: Hawkins, A R]]

[[Category: Lamb, H]]

[[Category: ~~Gonzalez~~-~~Bello~~, C]]

[[Category: Llamas-Saiz, A L]]

[[Category: Maneiro, M]]

[[Category: Otero, J M]]

[[Category: Peon, A]]

[[Category: ~~Van~~ Raaij, M.J]]

[[Category: Raaij, M J.van]]

~~[[Category: Llamas-Saiz, A~~.L]]

[[Category: Santiago, C]]

[[Category: Binding site]]

[[Category: Inhibitor]]

[[Category: Lyase]]

[[Category: Protein binding]]

[[Category: Shikimis acid pathway]]

[[Category: Substrate specificity]]

[[Category: Type 2 dehydroquinase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by a 3-dehydroquinic acid derivative==
+<StructureSection load='4v0s' size='340' side='right' caption='[[4v0s]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-The entry 4v0s is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4v0s]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V0S FirstGlance]. <br>
-Authors: Otero, J.M., Llamas-Saiz, A.L., Santiago, C., Lamb, H., Hawkins, A.R., Maneiro, M., Peon, A., Gonzalez-Bello, C., van Raaij, M.J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2HN:(1R,2S,4S,5R)-2-(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL-1,4,5-TRIHYDROXY-3-OXOCYCLOHEXANE-1-CARBOXYLIC+ACID'>2HN</scene>, <scene name='pdbligand=7HN:3,4-DIHYDROXY-2-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]BENZOIC+ACID'>7HN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
-Description: Crystal structure of Mycobacterium tuberculosis Type II Dehydroquinase D88N mutant inhibited by a 3-dehydroquinic acid derivative
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v0s OCA], [http://pdbe.org/4v0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4v0s RCSB], [http://www.ebi.ac.uk/pdbsum/4v0s PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Otero, J.M]]
+== Function ==
-[[Category: Hawkins, A.R]]
+[[http://www.uniprot.org/uniprot/AROQ_MYCTO AROQ_MYCTO]] Catalyzes a trans-dehydration via an enolate intermediate.
+__TOC__
+</StructureSection>
+[[Category: 3-dehydroquinate dehydratase]]
+[[Category: Gonzalez-Bello, C]]
+[[Category: Hawkins, A R]]
 [[Category: Lamb, H]]
-[[Category: Gonzalez-Bello, C]]
+[[Category: Llamas-Saiz, A L]]
 [[Category: Maneiro, M]]
+[[Category: Otero, J M]]
 [[Category: Peon, A]]
-[[Category: Van Raaij, M.J]]
+[[Category: Raaij, M J.van]]
-[[Category: Llamas-Saiz, A.L]]
 [[Category: Santiago, C]]
+[[Category: Binding site]]
+[[Category: Inhibitor]]
+[[Category: Lyase]]
+[[Category: Protein binding]]
+[[Category: Shikimis acid pathway]]
+[[Category: Substrate specificity]]
+[[Category: Type 2 dehydroquinase]]