4ww2: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8, Beta Chain-TRBV7-8, Antigen-presenting glycoprotein CD1d, and Beta-2-microglobulin==
 
<StructureSection load='4ww2' size='340' side='right' caption='[[4ww2]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
The entry 4ww2 is ON HOLD  until May 12 2017
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ww2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WW2 FirstGlance]. <br>
Authors: Le Nours, J., Praveena, T., Pellicci, D., Gherardin, N.A., Lim, R.T., Besra, G., Keshipeddy, S., Richardson, S.K., Howell, A.R., Gras, S., Godfrey, D.I., Rossjohn, J., Uldrich, A.P.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JLS:(15Z)-N-[(2S,3S,4R)-1-(ALPHA-D-GALACTOPYRANOSYLOXY)-3,4-DIHYDROXYOCTADECAN-2-YL]TETRACOS-15-ENAMIDE'>JLS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ww1|4ww1]]</td></tr>
Description:
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ww2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ww2 OCA], [http://pdbe.org/4ww2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ww2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ww2 PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Le Nours, J]]
== Disease ==
[[Category: Uldrich, A.P]]
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>  Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> 
[[Category: Howell, A.R]]
== Function ==
[[Category: Lim, R.T]]
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/CD1D_HUMAN CD1D_HUMAN]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:17475845</ref> 
[[Category: Richardson, S.K]]
== References ==
[[Category: Praveena, T]]
<references/>
[[Category: Rossjohn, J]]
__TOC__
[[Category: Gherardin, N.A]]
</StructureSection>
[[Category: Besra, G]]
[[Category: Gherardin, N A]]
[[Category: Godfrey, D I]]
[[Category: Gras, S]]
[[Category: Gras, S]]
[[Category: Godfrey, D.I]]
[[Category: Howell, A R]]
[[Category: Keshipeddy, S]]
[[Category: Keshipeddy, S]]
[[Category: Besra, G]]
[[Category: Lim, R T]]
[[Category: Nours, J Le]]
[[Category: Pellicci, D]]
[[Category: Pellicci, D]]
[[Category: Praveena, T]]
[[Category: Richardson, S K]]
[[Category: Rossjohn, J]]
[[Category: Uldrich, A P]]
[[Category: Immune system]]
[[Category: Immunity]]
[[Category: Natural killer t cell]]
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