4x1v: Difference between revisions

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'''Unreleased structure'''


The entry 4x1v is ON HOLD
==Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1==
 
<StructureSection load='4x1v' size='340' side='right' caption='[[4x1v]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
Authors: Rouka, E., Krojer, T., von Delft, F., Knapp, S., Kirsch, K.H., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Feller, S.M., Simister, P.C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4x1v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X1V FirstGlance]. <br>
Description: Crystal structure of the 2nd SH3 domain from human CD2AP (CMS) in complex with a proline-rich peptide (aa 76-91) from human ARAP1
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x1v OCA], [http://pdbe.org/4x1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x1v RCSB], [http://www.ebi.ac.uk/pdbsum/4x1v PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Arrowsmith, C.H]]
== Disease ==
[[Category: Feller, S.M]]
[[http://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN]] Defects in CD2AP are the cause of susceptibility to focal segmental glomerulosclerosis type 3 (FSGS3) [MIM:[http://omim.org/entry/607832 607832]]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.<ref>PMID:12764198</ref> 
[[Category: Kirsch, K.H]]
== Function ==
[[Category: Von Delft, F]]
[[http://www.uniprot.org/uniprot/CD2AP_HUMAN CD2AP_HUMAN]] Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.<ref>PMID:15800069</ref>  [[http://www.uniprot.org/uniprot/ARAP1_HUMAN ARAP1_HUMAN]] Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).<ref>PMID:11804590</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Delft, F von]]
[[Category: Edwards, A M]]
[[Category: Feller, S M]]
[[Category: Kirsch, K H]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
[[Category: Simister, P.C]]
[[Category: Krojer, T]]
[[Category: Rouka, E]]
[[Category: Rouka, E]]
[[Category: Edwards, A.M]]
[[Category: Simister, P C]]
[[Category: Krojer, T]]
[[Category: Endocytosis adaptor protein]]
[[Category: Bountra, C]]
[[Category: Kidney]]
[[Category: Protein-peptide binary complex]]
[[Category: Sgc]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]
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