4yky: Difference between revisions

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'''Unreleased structure'''


The entry 4yky is ON HOLD  until Mar 04 2017
==Heat Shock Protein 90 Bound to CS319==
 
<StructureSection load='4yky' size='340' side='right' caption='[[4yky]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
Authors: Kang, Y.N., Stuckey, J.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4yky]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YKY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YKY FirstGlance]. <br>
Description: Heat Shock Protein 90 Bound to CS319
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4EU:(2,4-DIHYDROXYPHENYL)(4-HYDROXYPHENYL)METHANONE'>4EU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ykq|4ykq]], [[4ykr|4ykr]], [[4ykt|4ykt]], [[4yku|4yku]], [[4ykw|4ykw]], [[4ykx|4ykx]], [[4ykz|4ykz]]</td></tr>
[[Category: Stuckey, J.A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yky FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yky OCA], [http://pdbe.org/4yky PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yky RCSB], [http://www.ebi.ac.uk/pdbsum/4yky PDBsum]</span></td></tr>
[[Category: Kang, Y.N]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Kang, Y N]]
[[Category: Stuckey, J A]]
[[Category: Chaperone]]
[[Category: Chaperone-inhibitor complex]]
[[Category: Hsp 90]]
[[Category: Protein-inhibitor complex]]

Revision as of 03:49, 10 March 2016

Heat Shock Protein 90 Bound to CS319

4yky, resolution 1.78Å

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