4z9g: Difference between revisions
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==Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry== | |||
<StructureSection load='4z9g' size='340' side='right' caption='[[4z9g]], [[Resolution|resolution]] 3.18Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4z9g]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z9G FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1Q5:3,6-DIMETHYL-N-(PENTAN-3-YL)-2-(2,4,6-TRIMETHYLPHENOXY)PYRIDIN-4-AMINE'>1Q5</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4k5y|4k5y]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z9g OCA], [http://pdbe.org/4z9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z9g RCSB], [http://www.ebi.ac.uk/pdbsum/4z9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z9g ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CRFR1_HUMAN CRFR1_HUMAN]] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:18801728</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Lysozyme]] | |||
[[Category: Bortolato, A]] | |||
[[Category: Cheng, R K.Y]] | |||
[[Category: Dore, A S]] | |||
[[Category: Hollenstein, K]] | [[Category: Hollenstein, K]] | ||
[[Category: | [[Category: Marshall, F H]] | ||
[[Category: | [[Category: Read, R J]] | ||
[[Category: | [[Category: Family b]] | ||
[[Category: | [[Category: G-protein]] | ||
[[Category: | [[Category: Gpcr]] | ||
[[Category: Hexagonal]] | |||
[[Category: Membrane]] | |||
[[Category: Membrane protein]] | |||
[[Category: Receptor]] | |||
[[Category: Signaling protein]] | |||
[[Category: Tnc]] | |||
Revision as of 10:13, 13 July 2016
Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395 in a hexagonal setting with translational non-crystallographic symmetry
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